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Intravenous Immunoglobulin (IVIG) is a blood product composed of pooled immunoglobulin G (IgG) antibodies extracted from the plasma of thousands of healthy donors. It is administered through a vein and is used to treat various immune deficiencies, autoimmune diseases, and inflammatory conditions. In primary immunodeficiency disorders, such as common variable immunodeficiency (CVID) or X-linked agammaglobulinemia, IVIG helps replace missing antibodies to prevent infections. It also plays a critical role in modulating the immune system in autoimmune diseases like Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), and immune thrombocytopenic purpura (ITP), where the immune system mistakenly attacks the body's own tissues.
The mechanism of action of IVIG is multifactorial and includes neutralization of autoantibodies, suppression of inflammatory cytokines, and modulation of Fc receptors on immune cells. IVIG therapy is generally well tolerated but may cause side effects such as headaches, fever, chills, or, more rarely, serious reactions like renal dysfunction or thromboembolic events. Dosage and frequency depend on the condition being treated and the patient’s clinical response. Due to its high cost and demand, IVIG is considered a critical therapeutic resource, and its use is carefully managed to ensure availability for patients with life-threatening conditions.
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Transplant diagnostics refers to the specialized tests and procedures used to evaluate donor-recipient compatibility in organ, tissue, and bone marrow transplantation. These diagnostics play a critical role in ensuring the success of transplants by minimizing the risk of immune rejection. Key diagnostic methods include human leukocyte antigen (HLA) typing, crossmatching, and antibody screening. HLA typing helps identify matching proteins on the surface of white blood cells, which are essential for immune system recognition. Crossmatching assesses whether the recipient's immune system will react against the donor organ, while antibody screening detects pre-existing antibodies that could cause transplant rejection.
The importance of transplant diagnostics has grown with advancements in molecular technologies such as polymerase chain reaction (PCR), next-generation sequencing (NGS), and flow cytometry, which offer high precision and faster results. Accurate transplant diagnostics not only improve graft survival rates but also aid in post-transplant monitoring by detecting early signs of rejection or infection. As the demand for organ transplants increases worldwide, the field of transplant diagnostics continues to evolve, contributing significantly to personalized medicine and better patient outcomes.
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